Follicular variant of peripheral T-cell lymphoma

Follicular variant of peripheral T-cell lymphoma

Blog Article

Globally, peripheral T-cell lymphomas (PTCLs) constitute about 12% of all non-Hodgkin lymphomas, of which the unspecified category is the most common subtype (30%).Mostly, the unspecified category shows a diffuse pattern of involvement in the Lighting lymph nodes.However, rarely, they may show a follicular/nodular pattern mimicking a follicular lymphoma.We report a case of a follicular variant of PTCL, not otherwise specified.

This case displayed a striking nodular/follicular pattern with an admixture of small (centrocyte-like) and large (centroblast-like) cells, thus mimicking a follicular lymphoma.The neoplastic cells were strongly positive for both CD3 and CD20.In addition, they were positive for pan T-cell markers and PD-1.T-cell receptor gene rearrangement studies Vegan highlighted a monoclonal T-cell population.

Even though this variant of PTCL is very rare, it is important to keep it as a differential for the lymphomas exhibiting nodular pattern.